||End-to-end route control spanning a set of networks can provide opportunities to both end users to optimize in- terdomain control and network service providers to increase business offering. BGP, the de facto interdomain routing pro- tocol, provides no programmable control. Recent proposals for interdomain control, such as MIRO, ARROW and SDX, provide more mechanisms and interfaces, but they are only either point or incremental solutions. In this paper, we provide the first, systematic formulation of the software-defined internetworking (SDI) model, in which a network exposes a programmable interface to allow clients to define the interdomain routes of the network, just as a traditional SDN switch exposes Openflow or another programmable interface to allow clients to define its next hops, extending SDN from intra-domain control to generic interdomain control. Different from intradomain SDN, which allows complete client control, SDI should also maximize network autonomy, such as by allowing a network to maintain the control of its interdomain export policies, to avoid fundamental violations such as valley routing. We define the optimal end-to-end SDI routing problem and conduct rigorous analysis to show that the problem is NP-hard. We develop a blackbox optimization algorithm, which leverages Bayesian optimization theory and important properties of interdomain routing algebra, to sample end-to-end routes sequentially and find a near-optimal policy- compliant end-to-end route with a small number of sample routes. We implement a prototype of our optimization algorithm and validate its effectiveness via extensive experiments using real interdomain network topology. Results show that in an interdomain network with over 60000 ASes and over 320000 AS- level links, in 80% experiment cases, the blackbox optimization algorithm can find a near-optimal policy-compliant end-to-end route by sampling less than 33 routes.